Lipoprotein(a), or Lp(a), is a cholesterol that can significantly increase your risk of heart disease and stroke. While genetics play a major role in Lp(a) levels, you’re not entirely powerless. Here’s a deeper dive into actionable steps you can take to potentially lower your Lp(a) and protect your heart health.
1. Manage Your LDL Cholesterol
This type of cholesterol can build up like plaque on the inside of your pipes, making it harder for blood to flow. By taking control of LDL, you may be able to lower your Lp(a) levels, as well.
- Talk to Your Doctor About Therapies and Medication: While statin therapy doesn’t directly lower Lp(a), they are crucial for managing LDL cholesterol, which is still a major risk factor. Work with your doctor to find the most effective statin and dosage for you.1 Additionally, ezetimibe is a medication that works differently than statins to further lower LDL cholesterol by 13-20%. Combining ezetimibe with a statin can provide an added benefit.2
- Explore PCSK9 Inhibitors: These newer injectable medications can dramatically lower LDL cholesterol and have shown some promise in modestly reducing Lp(a) as well.3
2. Lifestyle Modifications with a Purpose:
- Refined Carbohydrate Restriction: While a heart-healthy diet is always recommended, specifically limiting refined carbohydrates (white bread, sugary drinks, processed foods) may have a more targeted effect on Lp(a) compared to other dietary changes.
- Strategic Exercise: Regular aerobic exercise is beneficial for overall heart health, but some studies suggest that high-intensity interval training (HIIT) may be particularly effective in lowering Lp(a).
- Stress Management: Chronic stress can contribute to inflammation and may influence Lp(a) levels. Incorporate stress-reducing techniques like meditation, yoga, or spending time in nature.
3. Stay Informed and Proactive:
- Regular Monitoring: If you have elevated Lp(a), work with your doctor to monitor your levels regularly and adjust your treatment plan as needed.
- Genetic Testing: Consider genetic testing to assess your risk and determine if other family members might also benefit from screening.
- Participate in Research: Stay informed about ongoing research and consider participating in clinical research to contribute to the development of new Lp(a)-lowering therapies.
By taking a proactive and informed approach, you can take control of your Lp(a) and reduce your risk of cardiovascular (heart) disease.
References:
- Mayo Clinic. Statin Therapy. https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/statins/art-20045772. Accessed 2024.
- Cleveland Clinic. Ezetimibe. https://my.clevelandclinic.org/health/treatments/ezetimibe-tabletshttps://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/statins/art-20045772. Accessed 2024.
- Schwartz, Gregory G et al. “Lipoprotein(a) and Benefit of PCSK9 Inhibition in Patients With Nominally Controlled LDL Cholesterol.” Journal of the American College of Cardiology vol. 78,5 (2021): 421-433. doi:10.1016/j.jacc.2021.04.102
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